Comparations Of Glycated Albumin Among Type 2 Diabetes Mellitus Patient With Normoalbuminuria, Microalbuminuria And Macroalbuminuria

Raja Iqbal Mulya Harahap, N. Tristina, Ruri Rizki Anriani
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Abstract

Diabetic nephropathy is the most often complication of diabetes mellitus (DM). Complications of diabetic nephropathy can occur through several pathways, one of which is the formation of Advanced Glycation End Products (AGEs) through the formation of Glycated Albumin (GA). Glycated albumin (GA) is a medium-term glycemic control (2-3 weeks), shorter duration than HbA1c (2-3 months). The aim of this study was to compare the levels of GA in T2DM patients with normoalbuminuria, microalbuminuria, and macroalbuminuria. This is a cross-sectional study with subjects were 105 outpatients who had been diagnosed with T2DM by clinicians at Hasan Sadikin Hospital’s Endocrinology Clinic. We examined urinary albumin per Creatinine (u-ACR) and blood GA Increased GA level was found in 75.24% subjects. Kruskal Wallis test in GA serum levels of patients with T2DM normoalbuminuria group, microalbuminuria and macroalbuminuria revealed statistically significant (p <0.001), with median and range of GA in normoalbuminuria 15,9% (12,1-21,89)%; microalbuminuria 20,9% (12,9-47,2)%; dan macroalbuminuria 23,1% (13,6-46,1)%. Statistical analysis showed that the GA serum level was significantly different between T2DM patients with normoalbuminuria and macroalbuminuria, but not between those with microalbuminuria and macroalbuminuria (p=0.001 and p=0.137, respectively).  The result showed that the extensive kidney damage at the subject, the higher result of Glycated Albumin level in serum.
2型糖尿病正常白蛋白尿、微量白蛋白尿和大量白蛋白尿患者糖化白蛋白的比较
糖尿病肾病是糖尿病最常见的并发症。糖尿病肾病的并发症可通过多种途径发生,其中之一是通过糖化白蛋白(GA)的形成形成晚期糖基化终产物(AGEs)。糖化白蛋白(GA)是一种中期血糖控制(2-3周),持续时间短于糖化血红蛋白(2-3个月)。本研究的目的是比较正常白蛋白尿、微量白蛋白尿和大量白蛋白尿的T2DM患者的GA水平。这是一项横断面研究,研究对象为105名被哈桑萨迪金医院内分泌科诊所临床医生诊断为2型糖尿病的门诊患者。我们检测了尿白蛋白/肌酐(u-ACR)和血GA, 75.24%的受试者发现GA水平升高。Kruskal Wallis试验在T2DM正常白蛋白尿组、微量白蛋白尿组和大量白蛋白尿组患者血清GA水平显示有统计学意义(p <0.001),正常白蛋白尿组GA中位数和范围为15.9% (12.1 - 21.89)%;微量白蛋白尿20.9% (12.9 - 47.2)%;但大量蛋白尿23.1%(13.6 -46,1)%。统计分析显示,正常白蛋白尿和大量白蛋白尿的T2DM患者血清GA水平差异有统计学意义,而微量白蛋白尿和大量白蛋白尿的T2DM患者血清GA水平差异无统计学意义(p=0.001和p=0.137)。结果表明,受试者肾脏损害范围广,血清糖化白蛋白水平增高。
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