TNBC: A brief discussion on Triple Negative Breast Cancer

Abstract

TNBC; Triple negative breast cancer is one of the most aggressive type of breast cancer with a high reoccurrence and mortality rate. The reason behind its aggressive type is that TNBC do not have such specific receptors as other cancers. Substantially, Breast tumor cells carries receptors that work as doors for many mechanisms and hormone/enzyme based treatment. These receptors are estrogen (female hormone), Progesterone (female hormone) and HER-2 (Protein; Human epidermal receptor). Absence of these enzymes is result into the less option availability in cancer treatment. To find more possible treatments like chemotherapy, lumpectomy, radiation therapy and other gene therapy we first need to understand the concept behind occurrence and reoccurrence of TNBC. This review listed the possible study of triple negative breast cancer including its appearance in society and the molecular/genetic involvement. It is formerly known that cancer take place due to mutation in BRCA group of genes so it is important to know how it works in the case of TNBC. This study also summarizes the influence of anti-diabetic drug treatment (e.g. metformin) on diabetic cancer patients in order to cancer therapy of TNBC and effect of high glucose concentric cells on anti- cancer drug treatments and strategies for development in TNBC development. Keywords: TNBC; female hormone, breast cancer, BRCA group.