Relevancia de los enterovirus en la meningitis neonatal

IF 2.6 4区医学 Q3 INFECTIOUS DISEASES

Enfermedades infecciosas y microbiologia clinica Pub Date : 2024-01-01 DOI:10.1016/j.eimc.2022.07.010

Elisenda Moliner-Calderón , Núria Rabella-Garcia , Eulalia Turón-Viñas , Gemma Ginovart-Galiana , Josep Figueras-Aloy

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引用次数: 0

Abstract

Introduction

Enterovirus (EV) infections are the most frequent infections in the neonatal period and in many cases lead to hospital admission of the newborn (NB).

The aim of this study was to determine the incidence of EV in the etiology of neonatal meningitis and to define the clinical characteristics of newborns with EV meningitis.

Material and method

Retrospective observational cohort study. Including 91 NBs with meningitis and gestational age greater than 34 weeks gestational age (GA) attended in our center over a period of 16 years.

Results

The percentage of NBs with EV meningitis was higher than that of NBs with bacterial meningitis (BM) and accounted for 78% (n = 71). Half of the NBs with EV infection had a history of epidemic environment among their caregivers. Fever was present in 96% of cases as a clinical sign and, in general, sensory disturbances represented the main neurological alterations. Antibiotics (ATB) were given to 71.4% of patients with EV infection.

Detection of EV in CSF samples showed a high sensitivity for the diagnosis of EV meningitis. The most frequently implicated EV types were echovirus 11, coxsackievirus B5, echovirus 18, 25 and 7.

Conclusions

The results of this series show that enterovirus infection is a common cause of neonatal meningitis. These data underline the importance of rapid EV testing of infants with suspected meningitis. This allows early diagnosis and reduces antibiotic treatment, hospitalization time and related costs.

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肠道病毒与新生儿脑膜炎的相关性

导言肠道病毒（EV）感染是新生儿期最常见的感染，在许多情况下导致新生儿（NB）入院治疗。本研究旨在确定EV在新生儿脑膜炎病因中的发生率，并明确EV脑膜炎新生儿的临床特征。结果患 EV 脑膜炎的新生儿比例高于患细菌性脑膜炎（BM）的新生儿，占 78%（n = 71）。在感染 EV 的 NB 中，半数患者的护理人员有流行病环境史。96%的病例临床表现为发热，一般来说，感觉障碍是主要的神经系统改变。71.4%的EV感染患者使用了抗生素（ATB）。在脑脊液样本中检测EV显示出诊断EV脑膜炎的高灵敏度。最常见的 EV 类型为埃可病毒 11、柯萨奇病毒 B5、埃可病毒 18、25 和 7。这些数据强调了对疑似脑膜炎婴儿进行快速肠道病毒检测的重要性。这有助于早期诊断并减少抗生素治疗、住院时间和相关费用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Enfermedades infecciosas y microbiologia clinica 医学-传染病学

CiteScore

2.10

自引率

8.00%

发文量

194

审稿时长

29 days

期刊介绍： Hoy está universalmente reconocida la renovada y creciente importancia de la patología infecciosa: aparición de nuevos agentes patógenos, de cepas resistentes, de procesos con expresión clínica hasta ahora desconocida, de cuadros de una gran complejidad. Paralelamente, la Microbiología y la Infectología Clínicas han experimentado un gran desarrollo como respuesta al reto planteado por la actual patología infecciosa. Enfermedades Infecciosas y Microbiología Clínica es la Publicación Oficial de la Sociedad Española SEIMC. Cumple con la garantía científica de esta Sociedad, la doble función de difundir trabajos de investigación, tanto clínicos como microbiológicos, referidos a la patología infecciosa, y contribuye a la formación continuada de los interesados en aquella patología mediante artículos orientados a ese fin y elaborados por autores de la mayor calificación invitados por la revista.