Walsh-hadamard transform of DNA methylation profile for the classification of human cancer cells

Abstract

The discovery is reported on the low dimension and three step property of transform domain vector of of DNA methylation profile after Walsh-Hadamard Transform. The transform domain vector is unique for particular tissue type, and shows difference between normal and disease cells of the same tissue type. A new human disease cell classification approach is further proposed in this work, and the approach is tested with multiple datasets and classifiers. Results show that the proposed approach can achieve high classification accuracy and has great potential for practical applications.