Formulation and Characterization of Sustained Release Matrix Tablet of Pantoprazole

Mukesh Kumar, Deeksha Singh, Vatan Chaudhary
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Abstract

Pantoprazole is a proton pump inhibitor prodrug used in the treatment of gastric, duodenal ulcers and gastro esophageal reflux disease (GERD), Zollinger- Ellison syndrome. This is the most popular drug used in cure and maintenance therapy of peptic ulcer along with antibiotics. It suppresses the acid production by inhibiting the H+ K+ ATPase. Pantoprazole must be absorbed in the gastrointestinal tract and because it is unstable under acidic conditions, enteric delivery systems are required. The purpose of this study was to prepare matrix tablet using eudragit Rs 100, eudragit S100, and HPMC. On the basis of above result the formulation showed satisfactory result as it has the maximum release i.e. F5 66.50%in 10 hrs. Result of our study suggest that the matrix tablet containing pantoprazole may be suitable for the anti ulcer drug.
泮托拉唑缓释基质片的制备及表征
泮托拉唑是一种质子泵抑制剂前药,用于治疗胃、十二指肠溃疡和胃食管反流病(GERD)、佐林格-埃里森综合征。这是最常用的药物,用于治疗和维持治疗消化性溃疡与抗生素。它通过抑制H+ K+ atp酶来抑制酸的产生。泮托拉唑必须在胃肠道中被吸收,因为它在酸性条件下不稳定,所以需要肠内给药系统。本研究的目的是用乌桕r100、乌桕S100和HPMC制备基质片。在此基础上,该制剂在10 h内的最大释放度为66.50%,效果令人满意。本研究结果提示,含泮托拉唑的基质片可能适合作为抗溃疡药物。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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