Rapid Peripheral Nerve Imaging by Fluorescent Polymer Dots for Minimizing the Risk of Intraoperative Nerve Injury

Abstract

Iatrogenic nerve injury is an important cause of surgical complications. We focused on improving intraoperative visualization of nerves through highly fluorescent polymer dots (Pdots) and in vivo optical imaging instrumentation. The prepared Pdots have good biocompatibility, fluorescence stability, and simple preparation. Peripheral nerves can be imaged quickly with Pdots through a simple direct administration method and process, low non-specific absorption in the surrounding tissues. Moreover, the Pdots does not invade nerve cells but binds stably in the neural membrane structure. This study verifies that fluorescent Pdots have excellent neuroimaging capabilities and can be used for intraoperative visualization of peripheral nerves.