Nicola Marrano, G. Biondi, F. Giorgino, A. Natalicchio
{"title":"Fallimento β-cellulare nel diabete mellito di tipo 1 e di tipo 2: esistono meccanismi comuni?","authors":"Nicola Marrano, G. Biondi, F. Giorgino, A. Natalicchio","doi":"10.30682/ildia2202g","DOIUrl":null,"url":null,"abstract":"Type 1 diabetes (T1D) and type 2 diabetes (T2D) are two distinct diseases, with different etiology and pathogenesis, but with a common outcome (hyperglycemia), caused by almost complete or reduced loss of β-cell functional mass, respectively. Although the causes that lead to β-cell failure are different (typically immune-mediated for T1D, while related to metabolic stress for T2D), the underlying molecular pathways are almost sim¬ilar in both forms of diabetes. In this review we try to highlight common molecular mechanisms of β-cells damage in T1D and T2D, which could suggest new promising common therapeutic targets.","PeriodicalId":119243,"journal":{"name":"Il Diabete","volume":"28 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2022-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Il Diabete","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.30682/ildia2202g","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Type 1 diabetes (T1D) and type 2 diabetes (T2D) are two distinct diseases, with different etiology and pathogenesis, but with a common outcome (hyperglycemia), caused by almost complete or reduced loss of β-cell functional mass, respectively. Although the causes that lead to β-cell failure are different (typically immune-mediated for T1D, while related to metabolic stress for T2D), the underlying molecular pathways are almost sim¬ilar in both forms of diabetes. In this review we try to highlight common molecular mechanisms of β-cells damage in T1D and T2D, which could suggest new promising common therapeutic targets.