Alzheimer: A Complex Genetic Background

M. Calabrò, C. Crisafulli
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Abstract

Alzheimer is a complex, multifactorial disease with an ever increasing impact in modern medicine. Research in this area has revealed a lot about the biological and environmental underpinnings of this disease, especially its correlation with Β-Amyloid and Tau related mechanics; however, the precise biological pathways behind the disease are yet to be discovered. Recent studies evidenced how several mechanisms, including neuroinflammation, oxidative stress, autophagy failure and energy production impairments in the brain, −--- have been proposed to contribute to this pathology. In this section we will focus on the role of these molecular pathways and their potential link with Alzheimer Disease.
阿尔茨海默病:复杂的遗传背景
阿尔茨海默病是一种复杂的多因素疾病,对现代医学的影响越来越大。该领域的研究揭示了该病的生物学和环境基础,特别是与Β-Amyloid和Tau相关的机制;然而,这种疾病背后的确切生物学途径尚未被发现。最近的研究证明,包括神经炎症、氧化应激、自噬失败和大脑能量产生障碍在内的几种机制都被认为是导致这种病理的原因。在本节中,我们将重点关注这些分子途径的作用及其与阿尔茨海默病的潜在联系。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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