Alzheimer’s Disease: The Review from Pathophysiology to Future Direction

Technoarete Transactions on Recent Research in Applied Microbiology and Biotechnology Pub Date : 2023-02-01 DOI:10.36647/ttrramb/02.01.a002

P. Patel

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Abstract

According to estimates from 2021, dementia, which affects 52 million people worldwide, is primarily caused by Alzheimer's disease (AD). Over 65 million individuals in India are 65 years of age or older and dementia is more common as people age. Moreover, the neurotransmitter acetylcholine deficiency and oxidative stress brought on by the aggravation of glutamatergic transmission are linked to AD. This number of new cases is over 30% higher than the incidence reported in the WHO. Even after over a century of research, the pathophysiology of Alzheimer's disease remains a mystery, and there is no treatment that causes natural recovery. Beta fragments and neurofibrillary tangles as previously established are crucial markers for Alzheimer's disease. These deposits arise as a result of native proteins folding incorrectly Alzheimer's disease is linked to inflammatory processes. Tacrine, donepezil, memantine and thiazolidines drugs are used in the treatment of this disease to control the symptoms. Keyword : Alzheimer's disease, Pathophysiology, Therapy.

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阿尔茨海默病:从病理生理学到未来发展方向的综述

据估计，从2021年起，痴呆症影响着全球5200万人，主要由阿尔茨海默病(AD)引起。在印度，超过6500万人的年龄在65岁或以上，随着人们年龄的增长，痴呆症更为常见。此外，神经递质乙酰胆碱缺乏和谷氨酸传递加剧引起的氧化应激与AD有关。这一新病例数比世卫组织报告的发病率高出30%以上。即使经过一个多世纪的研究，阿尔茨海默病的病理生理学仍然是一个谜，也没有任何治疗方法可以使其自然恢复。β片段和神经原纤维缠结是阿尔茨海默病的重要标志。这些沉积是由于天然蛋白质折叠不正确导致的，阿尔茨海默病与炎症过程有关。治疗此病常用他克林、多奈哌齐、美金刚和噻唑烷类药物控制症状。关键词:阿尔茨海默病，病理生理，治疗

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Technoarete Transactions on Recent Research in Applied Microbiology and Biotechnology

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