Enhancing the drug encapsulation efficiency of liposomes for therapeutic delivery

Abstract

Nano-delivery vehicles have been a staple in point of care innovations for nearly two decades. Chief among these are liposomes, which are one of the best developed FDA delivery systems. A critical step of the optimization process is the loading of drugs within the core of the nano-carrier, known as encapsulation. Several procedures have been developed to increase the encapsulation efficiency, however, none are universal and can often change the native form of the drug. Here, we highlight an approach for rapidly and efficiently loading liposomes with the chemotherapeutic, Doxorubicin. We then use this method to deliver liposomal drugs to cancer cells in vitro.