Rasio Low Density Lipoprotein dan High Density Lipoprotein pada Preeklamsi Berat dibandingkan dengan Kehamilan Normal di Rumah Sakit Dr. Hasan Sadikin Bandung

Amran Amrullah, Budi Handono, Akhmad Yogi Pramatirta
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Abstract

Abstract Objective : This study aims to distinguish level of  (LDL/HDL)  and Low Density Lipoprotein/High Density Lipoprotein  ratio in severe preeclampsia patient compared to normal pregnancy. Method :  The study design was comparative cross-sectional study with consecutive sampling method that compared the laboratory results of LDL, HDL and ratio LDL/HDL that met the inclusion criteria. Subjects of this study were severe preeclampsia and normal pregnancy patient that fulfilled the inclusion criteria (n=60) in Dr. Hasan Sadikin General Hospital Bandung during August-September 2017. Result : It is revealed that the differences in level of LDL and LDL/HDL ratios in both groups were significant with p value ≤ 0,05. But there were no differences in HDL level. Increased level of LDL/HDL ratio in pregnancy was related to increased risk of preeclampsia with cut-off point> 2,632. If the increased level of LDL/HDL above cut-off point then the insident of severe preeclampsia increased 21,36 times. Conclusion : It was concluded that level of LDL and LDL/HDL ratios in severe preeclampsia were higher than in normal pregnancy. The increased LDL/HDL ratio of > 2.632 increased the risk of severe preeclampsia by 21.36 times. Perbandingan Rasio Low Density Lipoprotein/High Density Lipoprotein antara Preeklamsi Berat dan Kehamilan Normal di RSUP Dr. Hasan Sadikin Bandung Abstrak Tujuan : Penelitian ini adalah untuk mencari perbedaan rasio Low Density Lipoprotein/High Density Lipoprotein (LDL/HDL) pada preeklamsi berat dibandingkan dengan kehamilan normal sebagai faktor risiko timbulnya preeklamsi. Metode : Rancangan penelitian kasus kontrol membandingkan LDL, HDL, dan rasio LDL/HDL penderita preeklamsi berat dan kehamilan normal (n=60) bulan Agustus-September 2017 di Rumah Sakit Dr. Hasan Sadikin Bandung. Hasil : Hasil penelitian didapatkan perbedaan kadar LDL dan rasio LDL/HDL pada kedua kelompok secara bermakna dengan nilai p ≤0,05. Namun tidak didapatkan perbedaan yang bermakna pada kadar HDL. Peningkatan kadar LDL dan rasio LDL/HDL berhubungan dengan peningkatan risiko terjadinya preeklamsi dengan nilai cut-off > 2,632. Bila terjadi peningkatan rasio LDL/HDL diatas nilai cut-off maka risiko tejadinya preeklamsi berat sebesar 21,36 kali. Simpulan : Kadar LDL yang tinggi dan nilai cut-off rasio LDL/HDL >2,632 meningkatkan risiko terjadinya preeklamsi berat 21,36 kali Kata kunci : Preeklamsi, LDL, HDL, Rasio LDL/HDL
重量前的低密度脂蛋白和高密度脂蛋白比哈桑·萨德金医院的正常怀孕
摘要目的:本研究旨在区分重度子痫前期患者与正常妊娠患者的(LDL/HDL)水平及低密度脂蛋白/高密度脂蛋白比值。方法:采用连续抽样的比较横断面研究方法,比较符合纳入标准的LDL、HDL及LDL/HDL比值的实验室结果。本研究的对象为2017年8 - 9月万隆哈桑·萨迪金综合医院符合纳入标准的重度先兆子痫和正常妊娠患者(n=60)。结果:两组患者LDL水平及LDL/HDL比值差异均有统计学意义,p值≤0.05。但HDL水平无显著差异。妊娠期LDL/HDL比值升高与子痫前期风险增加相关,临界值> 2632。若LDL/HDL升高高于临界值,则重度子痫前期的发生率增加21,36倍。结论:重度子痫前期患者LDL水平及LDL/HDL比值均高于正常妊娠。LDL/HDL比值大于2.632时,发生严重子痫前期的风险增加21.36倍。低密度脂蛋白/高密度脂蛋白(LDL/HDL):低密度脂蛋白/高密度脂蛋白(LDL/HDL):低密度脂蛋白/高密度脂蛋白(LDL/HDL):低密度脂蛋白/高密度脂蛋白(LDL/HDL):低密度脂蛋白/高密度脂蛋白(LDL/HDL):低密度脂蛋白/高密度脂蛋白(LDL/HDL):Metode: Rancangan penelitian kasus kontrol membandingkan低密度脂蛋白,高密度脂蛋白,丹rasio LDL / HDL penderita preeklamsi培拉特丹kehamilan正常(n = 60) bulan Agustus-September哈桑博士2017年迪大Sakit Sadikin万隆。Hasil: Hasil penelitian didapatkan perbedaan kadar LDL/HDL LDL/HDL pada kedua kelompok secara bermakna dengan nilai p≤0.05。Namun tidak didapatkan perbedaan yang bermakna padada kadar HDL。低密度脂蛋白/高密度脂蛋白水平临界值> 2632。低密度脂蛋白/高密度脂蛋白(LDL/HDL)数据的研究进展[j], [j], [j]。Simpulan: Kadar LDL yang tinggi dan nilai cut-off rasio LDL/HDL >2,632 meningkatkan risiko terjadinya preeklamsi berat 21,36 kali Kata kunci: preeklamsi, LDL, HDL, rasio LDL/HDL
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