Verso una nuova fonte di β-cellule per la cura del diabete mellito di tipo 1

Abstract

Pluripotent stem cells are the best candidates for a renewable and infinite source of β-cells suitable for a future application in cell ther-apy for type 1 diabetes. Obtaining a cellular product that is safe and functional is becoming urgent, as the first clinical trials using stem cell-derived β cells are ongoing. This review summarizes the current strategies applied in the field of stem cell derived-β cells to improve in vitro differentiation and to solve the problems of tumorigenicity and immune rejection for a future stem cell based cell therapy.