[Penetration of radioactive hydrocortisone in human skin from various ointment bases. II. In vivo-experiments (author's transl)].

Archiv fur dermatologische Forschung Pub Date : 1975-07-18
A Zesch, H Schaefer
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Abstract

Absolute concentrations in the horny layer, epidermis, and dermis of therapeutical doses of topically applied hydrocortisone to human skin (in vivo) are reported. Using vaseline as vehicle 2-10(-4) molar concentrations are found in the epidermis and 3-10(-5) molar concentrations in the dermis. Further, three vehicles revealed minor concentrations. Comparison of the results with similar in vitro-investigations, reported earlier, allow to judge the resorption rate by the intact capillary system. Uptake of hydrocortisone by the vessels is observed. With high rates of penetration vasoconstriction seems to limit the resorption, while this is not the case with low rates, for instance with polyethyleneglycol as vehicle. Thus a differing drug liberation from the vehicle causes qualitatively different permeation kinetics. The elimination by urine, however, was practically the same. It is concluded that different vehicles may cause different therapeutic concentrations of the drug in the skin, but equal systemic side effects.

[不同软膏基的放射性氢化可的松在人体皮肤中的渗透。]2体内实验[作者译]。
在角质层,表皮和真皮的治疗剂量局部应用氢化可的松人皮肤(体内)的绝对浓度报告。以凡士林为载体,在表皮中发现2-10(-4)摩尔浓度,在真皮中发现3-10(-5)摩尔浓度。此外,有三辆车发现了少量的浓度。将结果与先前报道的类似体外调查结果进行比较,可以通过完整的毛细血管系统来判断吸收速率。观察到血管对氢化可的松的摄取。当渗透率高时,血管收缩似乎限制了吸收,而当渗透率低时则不是这样,例如用聚乙烯乙二醇作为载体。因此,不同的药物从载体中释放导致不同质的渗透动力学。然而,通过尿液排出的情况几乎是一样的。由此得出结论,不同的载药体可能导致不同的药物在皮肤中的治疗浓度,但相同的全身副作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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