Finding Correlated Mutations of Positions among Structural Proteins in SARS-CoV-2 Amino Acid Sequences

Abstract

In this paper, we find the correlated mutations of positions among structural proteins of spike, envelop, membrane and nucleocapsid proteins in amino acid sequences of SARS-CoV-2. Here, we adopt the algorithm designed by Shimada et al. (2012) of finding the correlated mutations formulated by joint entropy. In particular, we focus on whether or not the found correlated mutations contains spike protein substitutions in SARS-CoV-2 Delta variant.