Changes in the dynamic compliance coefficient of the lungs and breathing mechanics during administration of diethyl ether and halothane for general anaesthesia with spontaneous respiration.

A Budniewski
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Abstract

Changes of the dynamic compliance coefficient of lungs were studied during diethyl ether and halothane anaesthesia. Determining lung compliance at the same time it was possible to show the effect of these agents on changes in the magnitude of breathing work necessary to overcome elastic and non-elastic resistances. The investigations were carried out on 31 patients during general anaesthesia with spontaneous respiration. The determinations revealed that the tidal volume (TV) was decreased in relation to the initial values (before anaesthesia) indicating a depressing effect of these agents on the processes of respiration. Changes in the tidal volume and intrapulmonary pressure decided on the changes of the pulmonary compliance coefficient and the magnitude of breathing work. The coefficient of pulmonary compliance decreased during diethyl ether administration by 18.8% and during halothane by 30.9%. On the other hand the work necessary to overcome respiratory resistances increased mainly during ether anaesthesia owing to a significant rise in the non-elastic resistance (bronchial secretion).

乙醚和氟烷用于全身麻醉伴自主呼吸时肺动态顺应系数和呼吸力学的变化
研究了乙醚和氟烷麻醉期间肺动态顺应系数的变化。在确定肺顺应性的同时,有可能显示这些药物对克服弹性和非弹性阻力所需的呼吸功大小变化的影响。对31例全麻自主呼吸患者进行了调查。测定结果显示,潮气量(TV)相对于初始值(麻醉前)有所下降,表明这些药物对呼吸过程有抑制作用。潮气量和肺内压的变化决定了肺顺应系数的变化和呼吸功的大小。乙醚组肺顺应性系数下降18.8%,氟烷组肺顺应性系数下降30.9%。另一方面,由于非弹性阻力(支气管分泌物)的显著增加,克服呼吸阻力所需的功主要在乙醚麻醉期间增加。
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