Risk Factors for Mortality in Patients with Covid-19: A Systematic Review

Childhood Stunting, Wasting, and Obesity, as the Critical Global Health Issues: Forging Cross-Sectoral Solutions Pub Date : 2020-11-19 DOI:10.26911/the7thicph-FP.01.01

Ratna Yustinawati, A. Achadi

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引用次数: 1

Abstract

ABSTRACT Background: SARS-CoV-2, a new strain of the coronavirus, caused a global outbreak of fatal acute pneumonia. Globally, WHO has recorded 709,511 deaths from COVID-19, and the number is increasing. This study aimed to determine the risk factors for mortality in COVID-19 patients. Subjects and Method: A systematic review was conducted by searching for articles from ScienceDirect, PubMed, SpringerLink, Scopus, and Google Scholar databases. The inclusion criteria were open access, English-language, and full-text articles published in journals between 20019 and 2020. The keywords were (Coronavirus Disease 2019 AND clinical characteristics AND epidemiological characteristics AND comorbidities) OR (COVID-19 AND clinical characteristics AND epidemiological characteristics AND comorbidities). A total of eight articles was reviewed to answer the research question. The data were analyzed by PRISMA flow chart. Results: Based on the reports from China and Korea, a total of 1,314 (100%) COVID-19 patients who died was aged ≥60 years with comorbidity, in which 845 (64%) were male patients. Before the death of patients, the increase D-dimer level of ≥1 μg/ mL and Sequential Organ Failure Assessment (SOFA) score of ≥4 were reported. It indicated the occurrence of multi-organ failure and Acute Respiratory Distress Syndrome (ARDS). Most of the comorbidities were hypertension, diabetes mellitus, and cardiovascular diseases. Conclusion: Risk factors for mortality in COVID-19 patients include age at ≥60 years, male, and presence of comorbidity. The clinical features are D-dimer levels ≥1 μg / mL, high SOFA score (≥4), and ARDS. Comprehensive efforts are needed to identify risk factors early and conduct effective treatment timely to reduce the mortality of COVID-19 patients. Keywords: SARS-CoV-2, COVID-19, risk factors, mortality, comorbidity Correspondence: Ratna Yustinawati. Master of Public Health Program, Faculty of Public Health, Universitas Indonesia, Depok, West Java, Indonesia. Email: ratnayustinawati@gmail.com. Mobile: +628179324304. DOI: https://doi.org/10.26911/the7thicph.01.26

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Covid-19患者死亡的危险因素:一项系统综述

背景:新型冠状病毒SARS-CoV-2在全球范围内引发了致命性急性肺炎疫情。据世卫组织记录，全球已有709511人死于COVID-19，而且这一数字还在增加。本研究旨在确定COVID-19患者死亡的危险因素。研究对象和方法:通过从ScienceDirect、PubMed、SpringerLink、Scopus和Google Scholar数据库中检索文章进行系统评价。纳入标准是在20019年至2020年间发表在期刊上的开放获取、英语和全文文章。关键词为(2019冠状病毒病及其临床特征、流行病学特征及合并症)或(2019冠状病毒病及其临床特征、流行病学特征及合并症)。总共回顾了八篇文章来回答研究问题。采用PRISMA流程图对数据进行分析。结果:根据中国和韩国的报告，共有1314例(100%)死亡的COVID-19患者年龄≥60岁并伴有合并症，其中845例(64%)为男性患者。患者死亡前d -二聚体升高≥1 μg/ mL，顺序器官衰竭评估(SOFA)评分≥4分。提示多器官功能衰竭及急性呼吸窘迫综合征(ARDS)的发生。大多数合并症为高血压、糖尿病和心血管疾病。结论:COVID-19患者死亡的危险因素包括年龄≥60岁、男性和是否存在合并症。临床特征为d -二聚体水平≥1 μg / mL, SOFA评分高(≥4)，伴急性呼吸窘迫综合征(ARDS)。需要综合努力，及早发现危险因素，及时进行有效治疗，降低COVID-19患者死亡率。关键词:SARS-CoV-2, COVID-19，危险因素，死亡率，合并症印度尼西亚西爪哇德波市印度尼西亚大学公共卫生学院公共卫生硕士课程。电子邮件:ratnayustinawati@gmail.com。手机:+ 628179324304。DOI: https://doi.org/10.26911/the7thicph.01.26

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Childhood Stunting, Wasting, and Obesity, as the Critical Global Health Issues: Forging Cross-Sectoral Solutions

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