Protein Unfolding with MoS2/SnS2 Heterostructure

Abstract

In recent years, many diseases have been proved to be caused by abnormal protein sequences, so the protein sequencing has been a significant research topic. At the same time, nanopore technologies are striving to realize protein sequencing at single amino acid resolution. However, among the unsolved problems the unfolding of structured proteins into chain-like structures is a prerequisite for nanopore sequencing. In this work, we propose a general two-dimensional heterostructure that can be used for protein unfolding without the need for specific biological or chemical reagents. The role of two-dimensional heterostructures on protein unfolding is studied by molecular dynamics, which provides new inspiration for the subsequent experiments to achieve a general and reliable protein unfolding method.