The role of mitosis in the formation of binuclear cells with a pigmented epithelium of the retina and in the rat liver.

Abstract

The formation of binuclear tetraploid cells in the pigmented epithelium of the retina and the rat liver was investigated by the method of autoradiography using H3-thymidine. It was shown that binuclear cells are formed in these tissues as a result of incomplete mitosis. Only mononuclear diploid cells participate in the formation of these cells in the livers of 24-day-old animals, while in the pigmented epithelium of the retina of four-day-old animals, in addition binuclear tetraploid cells also participate. The duration of the phases of the mitotic cycle of cells of the pigmented epithelium of the rat retina and liver was determined.