Statistical analysis of echocardiography indices and indices of collagenolysis system in patients with chronic heart failure

2016 IEEE NW Russia Young Researchers in Electrical and Electronic Engineering Conference (EIConRusNW) Pub Date : 2016-02-01 DOI:10.1109/EICONRUSNW.2016.7448301

S. A. Pyko, N. Pyko, O. Markelov, M. Bogachev, E. Semernin, A. Poliakova, A. Krutikov, A. Totolian, A. Goodkova

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Abstract

We studied the interrelation between the echocardiographic indices and the indices of collagenolysis system in 68 patients with progressive chronic heart failure with preserved ejection fraction and thick walls of the left ventricle. We found that while the tissue inhibitor TIMP-1 level is independent of the left ventricular dilation status, after being normalized to the individual matrix metalloproteinases 1, 3, 9 levels it appears significantly higher in patients without left ventricular dilation indications. Therefore we suggest that the matrix metalloproteinases levels are more important diagnostic indicators in patients with dilation than the TIMP-1 level itself. Furthermore, significant cross-correlations between the echocardiographic indices and the indices of collagenolysis system have been observed and quantified by linear regression analysis. The found relations could appear useful in the dilation status prediction as well as in the heart failure prognosis.

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慢性心力衰竭患者超声心动图指标及胶原溶解系统指标的统计分析

本文对68例左心室壁厚、射血分数保留的进行性慢性心力衰竭患者的超声心动图指标与胶原溶解系统指标的相关性进行了研究。我们发现，虽然组织抑制剂TIMP-1水平与左室舒张状态无关，但在标准化到个体基质金属蛋白酶1,3,9水平后，在没有左室舒张指征的患者中，TIMP-1水平明显更高。因此，我们认为基质金属蛋白酶水平是比TIMP-1水平本身更重要的诊断指标。此外，超声心动图指标与胶原溶解系统指标之间存在显著的相互关系，并通过线性回归分析进行量化。所发现的关系对舒张状态的预测和心力衰竭的预后有一定的指导意义。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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2016 IEEE NW Russia Young Researchers in Electrical and Electronic Engineering Conference (EIConRusNW)

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