[Excision repair in lymphocytes of psoriasis (author's transl)].

Archiv fur dermatologische Forschung Pub Date : 1975-01-01
E Bohnert, E G Jung
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Abstract

Psoriasis is a autosomal hereditary disease of the skin, which has been treated with a great number of possibly carcinogenic substances. No increase of maligonomies has been observed except for the tumors induced by arsenic. The question may be asked whether the psoriatic cell has additional or more effective mechanisms to eliminate onocogenic somatic mutations. In this study the capacity of the excision repair of circulating blood lymphocytes from 12 psoriatic patients has been investigated and compared to a control group of equal size. After irradiation with ultraviolet light, the lymphocytes are incubated with 3 H-thymidine and at various intervals the radioactivity in the cell material precipitated with perchloric acid is measured. It appears, that the excision reapir in lymphocytes from patients with psoriasis and normal persons is equal. In addition, the influence of hydroxyurea on the thymidine incorporation in lymphocytes has been studied.

[银屑病淋巴细胞的切除修复(作者译)]。
牛皮癣是一种常染色体遗传病的皮肤,它已经用大量的可能致癌的物质治疗。除砷引起的肿瘤外,未观察到恶性肿瘤的增加。问题可能是银屑病细胞是否有额外或更有效的机制来消除致瘤体细胞突变。在这项研究中,研究了12名银屑病患者的循环血液淋巴细胞的切除修复能力,并与同等大小的对照组进行了比较。经紫外光照射后,用3h -胸腺嘧啶孵育淋巴细胞,在不同时间间隔用高氯酸沉淀细胞物质,测定其放射性。由此可见,银屑病患者淋巴细胞的切除修复率与正常人相当。此外,还研究了羟基脲对淋巴细胞胸苷结合的影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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