Hepatorenal Effect of Single or Combined Moringa Olivera and Citrullus Colocynthis on Carbon Tetrachloride-Induced Injury in Spurge Dawely Rat

Abstract

Medicinal plants consider a source of potential drug, adjuvant or protective agent against hepatorenal toxic chemicals. Liver and kidney diseases of different domestic animals resulted from different agents, antibiotics, plants toxin and even post vaccinal reaction. To better understand the potential of single or combined Moringa Olivera and Citrullus Colocynthis on carbon tetrachloride-induced injury in 70 male spurge dawely rat. Carbon tetrachloride at dose of 0.5ml/kg (10% in olive oil) for 8 weeks increased significantly level of creatinine while reduced significantly level of blood urea and non-significantly reduced level of total protein and albumin. Additionally, Moringa oleifera at dose of 250 and 500 mg/kg increased significantly level of glucose and total protein and albumin while retained creatinine to quite similar level to control group. Additionally, Citrullus colocynthis at dose of 12.5 and 25 mg/kg increased significantly level of blood urea and total protein while non-significantly increased of creatinine level and reduced significantly level of glucose. Kidney and liver of rats treated with combiend moringa oleifera at dose of 250 mg/kg and citrullus colocynthis at dose of 12.5 mg/kg with carbon tetrachloride at dose of 0.5ml/kg (10% in olive oil) retain liver and kidney weight and structure to quite like control group even fail to retain creatinine level to basal level due to present of infiltrate or cast blocked renal tubules