Granulomatous pneumonitis. A result of intrapleural instillation of quinacrine and talcum powder.

Archives of pathology Pub Date : 1975-09-01
S M Factor
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Abstract

A 73-year-old man with bilateral recurrent pleural effusions had relief of symptoms with intrapleural instillation of quinacrine hydrochloride and talcum powder. At postmortem, examination of the lungs showed granulomatous consolidation of a portion of the lower lobe of the left lung. The granulomatous reaction was in response to large numbers of talc and quinacrine crystals within the pulmonary parenchyma. A review of the literature disclosed no reports of pulmonary damage following the intrapleural administration of these two agents. This unusual complication of therapy may have resulted from the aspiration of crystals through a small, undetected bronchopleural fistula.

肉芽肿性肺炎。胸膜内注射奎宁和滑石粉的结果。
73岁男性双侧反复胸腔积液,经胸腔内灌注盐酸阿奎宁和滑石粉后症状缓解。死后,肺部检查显示左肺下叶部分肉芽肿实变。肉芽肿反应是对肺实质内大量滑石粉和阿奎宁晶体的反应。文献回顾显示,胸膜内注射这两种药物后没有肺损伤的报道。这种不寻常的并发症可能是由于晶体通过一个小的,未被发现的支气管胸膜瘘管吸入所致。
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