The potential of clustered core magnetic particles for MPI

Abstract

No obvious differences between the structures of the different particles were found, yet their MPI efficacy varies significantly: the MPS amplitude differs by a factor of up to 6 in the lower and 11 in the higher harmonics between the highest (#1) and lowest (#2) MPI efficacy particles synthesized here. In comparison to Resovist and FeraSpin R this means an improvement by a factor of about three in the lower and two in the higher harmonics in case of the high efficacy particles (#1). Our results from static magnetization measurements allow to quantitatively understand this increase. Such an increase does not represent the theoretical limit, but so far similar performance was only found for size optimized particles obtained from the best state-of-the-art clustered core MPI tracer Resovist and FeraSpin R from aqueous synthesis [2,3] as well as certain mono-crystalline core particles from organic synthesis [4].