Towards Biological Modules Identification: An Application of Elementary Flux Mode Analysis

Abstract

There are lots of attempts to obtain functional modules in biological networks based on graph theory. However, biological networks differ from general graphs (or complex networks), and thus in most cases, these attempts can not obtain suitable units with biological significance. Herein, after the introduction of the basic for elementary flux mode (EFM) analysis, we analyze the vitamin B2 metabolism. We found that elementary flux mode analysis could identify biologically functional modules in biological networks.