Features of infertility for women with different thyroid violations

Abstract

The objective: study of frequency and structure of thyroid violations for women with infertility. Materials and methods. For the performance of the put goal the screening estimation of pathology of thyroid was conducted for 298 women with infertility (basic group) and at 50 fertile of women which appealed to the clinic for the selection of method of contraception (control group). The inspection of patients with infertility was conducted in accordance with the generally accepted diagnostic algorithm, including endoscopic methods, and treatment – depending on found out reasons of infertility Results. Leading place in the structure of reasons of infertility for women with autoimmune thyroiditis occupied outward genital endometriosis (34,4%), for women with found out a thyroprivia is an endocrine factor of infertility (syndrome of polycystic ovaries) – 29,8%, for patients with the compensated thyroprivia is outward genital endometriosis (26,6%), for women with a euthyroid goitre and for patients without pathology of thyroid is a pipe-peritoneal factor (33,3% and 39,8% accordingly). For patients with autoimmune thyropathy high-frequency of unmaturing of pregnancy is characteristic – at 2–2,4 time which exceeds analogical indexes in a control group. Conclusion. For patients with infertility prevalence of thyroid pathology at 3,8 time higher by comparison to fertile women (48% and 12,5% accordingly). In the structure of pathology of thyroid the transmitter of antibodies prevails to thyroperoxidase in combination with the ultrasonic signs of autoimmune thyroiditis (24% and 8,7% accordingly); subclinical thyroprivia as a result of autoimmune thyroiditis (8,6% and 2,5% accordingly); euthyroid goitre (7,8% and 2,5% accordingly). The results of questionnaire, conducted for women with infertility, showed the low diagnostic value of clinical симптоматики of thyroprivia by comparison to laboratory diagnostics in verification of this diagnosis. A sensitiveness of symptoms was low and hesitated from 16,1% to 27,8%, while specificity of symptoms was considerable and varied from 85,1% to 94,5%.