Characterization of liquid jet injection into tissue based on optical coherence tomography

2013 Transducers & Eurosensors XXVII: The 17th International Conference on Solid-State Sensors, Actuators and Microsystems (TRANSDUCERS & EUROSENSORS XXVII) Pub Date : 2013-06-16 DOI:10.1109/TRANSDUCERS.2013.6627107

K. Mutschler, L. Tanguy, N. Weber, A. Ernst, R. Zengerle, P. Koltay

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Abstract

We present the combination of high speed video monitoring, force measurement and Optical Coherence Tomography (OCT) as a new method for the characterization of liquid jets for needle-free tissue injection applications. It is well known that physical parameters, such as jet velocity and jet diameter determine the penetration characteristics of liquid micro-jets into a specific tissue [1]. The optimum injection parameters vary significantly for different types of tissues. Therefore, we have used high speed video monitoring and force sensor measurements to characterize the liquid jet. The penetration into the tissue is then analyzed by Optical Coherence Tomography (OCT) [2]. This enables the general description of the specific jet's physical properties as well as the penetration characteristics with respect to a specific tissue. In the experimental study, jets with diameters of 100 μm and jet lengths from 6 to 18 ms (~ 2 to 9 μl) have been injected into colon tissue from pigs.

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基于光学相干层析成像的液体喷射入组织表征

我们提出了高速视频监控、力测量和光学相干断层扫描(OCT)的结合，作为一种表征无针组织注射应用中液体射流的新方法。众所周知，射流速度、射流直径等物理参数决定了液体微射流对特定组织的穿透特性[1]。不同类型组织的最佳注射参数差异很大。因此，我们使用高速视频监控和力传感器测量来表征液体射流。然后通过光学相干断层扫描(OCT)分析穿透组织的情况[2]。这使得能够对特定射流的物理特性以及相对于特定组织的穿透特性进行一般描述。在实验研究中，将直径为100 μm、射流长度为6 ~ 18 ms (~ 2 ~ 9 μl)的射流注入猪结肠组织。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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2013 Transducers & Eurosensors XXVII: The 17th International Conference on Solid-State Sensors, Actuators and Microsystems (TRANSDUCERS & EUROSENSORS XXVII)

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