The Effects of Ethanolic Extract of Premature Carica papaya (Pawpaw) Fruits on the Reproductive System of Female Wistar Rats

Scholars International Journal of Anatomy and Physiology Pub Date : 2023-03-11 DOI:10.36348/sijap.2023.v06i03.001

Victor P. D., O. S., Ogaree T. B, Nkoju, T. C., A. T., Ajie P. C., Wami-Amadi C. F., Okpara P. E., R. E., Ekokodje J. W., Dan-Jumbo D., Tee G. P., Jaja N. B.

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Abstract

In recent times, different plant extracts have been reported to exert fertility enhancing effects. Carica papaya fruit is known for its use in preparation of herbal remedies. The aim of this study is to investigate the effects of Carica papaya on the reproductive system of female Wistar rats. Sixteen (16) female Wistar rats with regular oestrous cycle were used for this study. Animals were grouped into four (4) groups (control, low dose, middle dose, and high dose) of 4 animals each. Carica papaya fruit extract was administered for 14 days while monitoring the oestrous cycle. Twenty hours after the last administration, animals were sacrificed, and blood samples taken. Blood samples were collected for hormonal assay. Data obtained was expressed as Mean ± standard deviation, values were considered statistically significant when P ≤ 0.05. Phytochemical analysis of premature Carica papaya fruit revealed the presence of alkaloids, terpenes, sterols and terpenoids were heavily present. Estrous cycle was not altered. Serum FSH and LH increased. The extract is likely to possess fertility enhancing properties.

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早熟木瓜果实乙醇提取物对雌性Wistar大鼠生殖系统的影响

近年来，不同的植物提取物被报道具有增强生育力的作用。番木瓜果实以其在草药制剂中的用途而闻名。本研究旨在探讨番木瓜对雌性Wistar大鼠生殖系统的影响。本研究选用16只雌性Wistar大鼠，其发情周期正常。将动物分为4组(对照组、低剂量组、中剂量组、高剂量组)，每组4只。给予番木瓜果实提取物14 d，同时监测发情周期。最后一次给药20小时后，处死动物，并采集血液样本。采集血样进行激素检测。所得数据以均数±标准差表示，P≤0.05认为值有统计学意义。对早熟番木瓜果实的植物化学分析表明，番木瓜果实中含有大量的生物碱、萜烯、甾醇和萜类。发情周期没有改变。血清FSH和LH升高。该提取物可能具有增强生育能力的特性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Scholars International Journal of Anatomy and Physiology

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