Correlation of Metabolic Syndrome in Different Phenotypes of Polycystic Ovary Syndrome and Pregnancy Rate

Abstract

Introduction: Polycystic ovary syndrome (PCOS) is considered one of the most common endocrine and metabolic disorders in women of reproductive age. According to Rotterdam diagnostic criteria, Insulin resistance (IR) plays an important role in the pathophysiology of PCOS. Aim of the study: To study the prevalence of metabolic syndrome in different phenotypes of PCOS and its relation to pregnancy rate. Subjects and methods: The current study recruited 100 patients who were primarily diagnosed with PCOS. These patients (aged between 18-30 years) complained of irregular menstruation, signs of hyperandrogenism, and infertility. Consents were taken from all patients. Cases were classified into four phenotypes (A, B, C, and D). After reporting the clinical history, physical examinations were performed by measuring arterial blood pressure (ABP), height, weight, body mass index (BMI), abdominal circumference (AC), and assessment of clinical signs of hyperandrogenism. the study found that the classic PCOS phenotype (A and B) is the most common representing about 60 % of patients. In comparison, the ovulatory phenotype (C) and the normal-androgenic phenotype (D) represented 27% and 13% of the patients, respectively. It also revealed a statistically significant difference between the four groups of PCOS regarding the presence of Metabolic Syndrome (P< 0.05), with the highest prevalence in phenotype A and the least prevalence in phenotype D. It also revealed a statistically significant difference between the four groups of PCOS regarding the presence of Metabolic Syndrome (P< 0.05), with the highest prevalence in phenotype A and the least prevalent phenotype D. Conclusion: Hyperinsulinemia and hyperandrogenemia can affect fertility in patients with PCOS leading to chronic anovulation.