Prognostic Contribution of the New Immunoglobulin (Ig) Biomarkers (Freelite™ and Hevylite™) in Waldenstrom's Macroglobulinemia (WM)

American Journal of Medicine and Medical Sciences Pub Date : 2012-12-01 DOI:10.5923/J.AJMMS.20120206.05

M. Kyrtsonis, E. Koulieris, D. Maltezas, T. Tzenou, S. Harding, E. Kastritis, N. Kafassi, Vassiliki Bartzis, A. Efthymiou, K. Bitsanis, M. Gavriatopoulou, E. Terpos, C. Kalpadakis, M. Angelopoulou, T. Vassilakopoulos, A. Bradwell, P. Beris, G. Pangalis, P. Panayiotidis, M. Dimopoulos

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Abstract

Clinical utility of serum free light chains (sFLC) and heavy chain (HLC) IgM were assessed, using Freelite and Hevylite assays in 70 WM patients. The result showed that median involved (i) sFLC -kappa and -lambda were 45.6 and 78.3mg/ L respectively; median sFLC (kappa+lambda) was 67.4 mg/ L. While, median FLCR (involved/uninvolved FLC ratios) were 2.7 and 6.9 in ikappa- and ilambda -restricted patients respectively. Moreover, increased isFLC, sFLC (kappa+lambda) and FLCR were correlated significantly with shorter time to first treatment (TFT) and adverse survival (OVS). Median iIgM-kappa and iIgM -lambda were 25.4 and 34.8g/L respectively; median HLCR (involved/uninvolved HLC ratios) were 185.5 and 101.9 in kappa- and lambda- restricted patients respectively. In addition, the increased iHLC and HLCR correlated significantly with shorter TFT. Hence, sFLC and HLC measurements appeared to be both prognostic in WM.

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新的免疫球蛋白(Ig)生物标志物(Freelite™和Hevylite™)在Waldenstrom大球蛋白血症(WM)中的预后贡献

采用Freelite和Hevylite法对70例WM患者进行血清游离轻链(sFLC)和重链(HLC) IgM的临床应用评估。结果表明(1)sFLC -kappa和-lambda的中位数分别为45.6和78.3mg/ L;中位sFLC (kappa+lambda)为67.4 mg/ l，而ikappa和ilambda限制患者的中位FLCR(累及/未累及FLC比率)分别为2.7和6.9。此外，isFLC、sFLC (kappa+lambda)和FLCR升高与首次治疗时间(TFT)缩短和不良生存期(OVS)显著相关。iIgM-kappa和iIgM -lambda的中位数分别为25.4和34.8g/L;kappa-和lambda-受限患者的中位HLCR(累及/未累及HLC比率)分别为185.5和101.9。此外，iHLC和HLCR的增加与TFT的缩短显著相关。因此，sFLC和HLC测量似乎对WM的预后都有影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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American Journal of Medicine and Medical Sciences

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