COMPARISON POTENCY ASSAY METHODS AS PLAQUE FORMING UNIT (PFU) AND CELL CULTURE INFECTIOUS DOSE 50% (CCID50) OF THE CANDIDATE NATIONAL REFERENCE STANDARD MEASLES VACCINE

Phạm Văn Hùng
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Abstract

A comparative study of two methods (PFU and CCID50) for potencydetermination for the national standard candidate measles vaccine was organized atthe National Institute for Control of Vaccines and Biologicals (NICVB). Twomethods are performed on the groups of candidate National Reference Standardmeasles vaccine derived from AIK-C strain stored at different temperatures: -700C,40C/7 days, 370C/7 days. The results show that although there is a difference, strongcorrelation exists between the two methods CCID50 and PFU with R2=0,886, r =0,94, coefficient PFU/CCID50 = 1.28 equivalent to the ratio PFU: CCID50 = 1:0.78.
比较效力测定方法作为菌斑形成单位(pfu)和细胞培养感染剂量50% (ccid50)的候选国家参比标准麻疹疫苗
在国家疫苗和生物制品控制研究所(NICVB)组织了两种方法(PFU和CCID50)测定麻疹国家标准候选疫苗效力的比较研究。采用-700℃、40℃/7天、370℃/7天对AIK-C株麻疹候选国家参比标准疫苗进行两种保存方法。结果表明,虽然存在差异,但两种方法CCID50与PFU之间存在较强的相关性,R2= 0.886, r = 0.94,系数PFU/CCID50 = 1.28,相当于PFU: CCID50 = 1:0.78。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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