Pathogenetic mechanisms in development of atrial fibrillation associated with new coronavirus infection (review article)

Abstract

The lack of research and formed ideas on the pathogenetic nature of arrhythmia associated with COVID-19 makes it difficult to assess and predict its development, as well as the choice of a strategy to prevent its formation. COVID-19 has a direct impact on the cardiovascular system, and in severe cases, it entails adverse consequences for the patient. The links of pathogenesis that form various disorders in the cardiovascular system are unclear and remain unexplored. The purpose of the study: based on the studied literature, to present and systematize possible pathophysiological mechanisms that can potentiate the development of various arrhythmias, including atrial fibrillation in patients who had a coronavirus infection. Materials and Methods. A literature review of scientific papers over the past 3 years was carried out in the search engines PubMed and eLIBRARY using keywords. For this meta-analysis, we used articles containing the evidence and experimental base on the most recent issues related to the epidemiology and pathophysiology of arrhythmias in patients who underwent a new coronavirus infection SARS-CoV-2 – atrial fibrillation. For the systematization of facts and a detailed study of literary sources in scientific work, general theoretical research methods were used: methods of analysis and synthesis. Results and Discussion: we present data of epidemiology, pathophysiology of the most frequent arrhythmias in patients who had a new coronavirus infection SARS-CoV-2 – atrial fibrillation. Conclusion. Transferred COVID-19 infection has a direct impact on the possibility of developing rhythm disturbances, which pose a significant danger to the life quality in patients with a new coronavirus infection.