"The Effect of Tissue Organization and Homeostasis on Inflammatory Cytoskeletal Signaling in Cancer"

Abstract

Tissue organization and homeostasis are based on a set of circuits that include inflammatory signaling that regulates the tissue environment. Imbalance of these connections may lead to inflammatory diseases and suppression of the immune system, as occurs in chronic viral infections and cancer [1]. With interferon type I (IFN-Is) as key stimuli IFN-I are produced by virus-infected cells to create an inherent cellular antiviral status in neighboring cells to eliminate infection. However, long-term IFN-I signaling leads to impaired immune function by inducing suppressive agents that impair immunity to promote tissue organization and homeostasis [2]. Imbalance of these connections may lead to inflammatory diseases and immunosuppression, as occurs in chronic viral infections and cancer, with interferon type I (IFN-Is) as key stimuli of IFN-I by cells. They become infected with the virus to create an inherent cellular antiviral status in neighboring cells to fight infection. However, long-term IFN-I signaling leads to immune dysfunction by inhibiting suppressive agents that inhibit immune enhancement [2,3].