Efficacy of Shallots Infusion (Allium Cepa L.) as an Antidiarrhea in Mice (Mus Musculus)

A. S. Purohita, A. Mustika, L. N. Sutardi, Amaq Fadholly
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Abstract

Shallots have been used for generations as traditional medicine, one of which is used in the treatment of diarrhea. This study determinedthe antidiarrheal activity of the shallot bulbs using intestinal protection and intestinal transit methods, and to determine the effective concentration that gives the best antidiarrheal effect in mice. This study used thirtymiceanddivided into six groups.The negativecontrol groupwas givenTween 80 (1%), positivecontrol group was given LoperamideHCl, and four various concentrations of shallot infusion treatment groups (1.25%, 2.5%, 5%, and 10 %). The treatment was given by the oral route. The parameters used in the intestinal protection method were frequency of defecation and fecesconsistency, while in intestinal transit method the parameters used were the percentage ratio of the marker trajectories compared to the overall length of the intestine. The results showed that the 1.25% concentration of shallot infusion indicatedthe best antidiarrheal activity and had a smaller ratio or stronger inhibition tointestinal peristalticcompared toall other concentrations, 2.5%, 5%, dan 10%. We concludedthat shallot bulbs infusion with a concentration of 1.25% has the most effective anti-diarrheal effect. This research can be continued by measurement of other diarrheal parameters such asstool weight, as well as start and stop time of diarrhea to further clarify the anti-diarrheal potential of shallot bulb infusion
葱冲剂对小鼠止泻作用的研究
青葱作为一种传统药物已经被使用了好几代,其中一种被用于治疗腹泻。本研究采用肠保护法和肠转运法测定大葱球茎的止泻活性,并确定其在小鼠体内的有效止泻浓度。这项研究使用了30只老鼠,分为6组。阴性对照组给予盐酸洛哌胺80(1%),阳性对照组给予盐酸洛哌胺80(1.25%、2.5%、5%、10%)4个不同浓度的葱输注治疗组。治疗是口服的。肠道保护法中使用的参数是排便频率和粪便浓度,而肠道运输法中使用的参数是标志物轨迹与肠道总长度的百分比比率。结果表明,与2.5%、5%和10%的其他浓度相比,1.25%的葱液止泻活性最好,对肠道蠕动的抑制比例更小或更强。我们得出的结论是,以浓度为1.25%的大葱输注具有最有效的止泻作用。本研究可通过测量大便重量、腹泻起止时间等其他腹泻参数继续进行,进一步明确葱球输注的抗腹泻潜力
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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