Haemostasis in acute myocardial infarction

Abstract

Acute myocardial infarction (AMI) is caused by a localized arterial thrombosis, which resulted with myocardial ischemia and necrosis. This event causes the reaction of heart muscle (akinesis and dyskinesis of the ischemic parts of myocardial wall, arrhythmias, and haemodinamic disturbances) and severe systemic reaction (activation of neuroendocrine axis and inflammatory response). Haemostatis disturbances, which can be detected during the AMI and partly caused by the local coronary thrombosis, and partly by the mentioned heart and systemic reaction. A number of therapeutic procedures like venepuncture and almost all drugs commonly used, also influence the measurement of haemostatic parameters. Premorbid state, like smoking diabetes, hyperchlosterolemia, hypertension and obesity and also strong modulators of haemostatis disturbances in AMI and to light on the main factors which modulate that complicated process.