Use of Acarizax® drug solution to perform skin prick tests to confirm patient sensitization to house dust mites.

E. Nazarova, Anastasia S. Primak
{"title":"Use of Acarizax® drug solution to perform skin prick tests to confirm patient sensitization to house dust mites.","authors":"E. Nazarova, Anastasia S. Primak","doi":"10.36691/rja3911","DOIUrl":null,"url":null,"abstract":"Objective: To assess the possibility of using a drug solution of Acarizax containing Derm house dust allergens. pteronyssinus and Derm. farinae in equal amounts - 12 SQ-HDM, in order to conduct skin prick tests to confirm the sensitization of patients to ODP.Methods: Skin prick tests with dilutions 1 tablet per 2.5 and 5 ml diluting liquid of the study drug with positive and negative controls. Statistical data processing was carried out using the Statistica 13.3 or IBM SPSS 17.0 software package. To analyze efficacy and safety data, standard parametric tests were used: Student's t-test for dependent/independent samples, analysis of variance (ANOVA) for repeated measurements, Mann-Whitney U-test, Shapiro-Wilk test. The analysis of AEs was planned to be based on an estimate of the frequency of AEs/serious AEs.Results: The correlation between the total level of specific IgE to tick allergens Derm was assessed. pteronyssinus and Derm. farinae measured at screening and papule size 20 minutes after application of the drug at a dilution of 1 tablet per 2.5 ml and 5 ml of diluting liquid - the correlation coefficient (r) in both groups (general) was 0.735 (high correlation), and 0.762 (high correlation) respectively. The result is statistically significant (p0.05) in both groups. A clinical trial has shown that the drug Acarizax, containing house dust allergens Derm. pteronyssinus and Derm.s farinae in equal amounts - 12 SQ-HDM, when used for the purpose of skin prick tests to confirm the sensitization of patients to ODP, is a safe and informative method.Conclusions: In order to conduct skin prick tests to confirm the sensitization of patients to ODP, the study drug can be used in a larger dilution - 1 tablet per 5 ml of diluting liquid. Acarizax medicinal product containing house dust allergens Derm. pteronyssinus and Derm. farinae in equal amounts - 12 SQ-HDM, when used for skin prick tests, is informative and well tolerated by patients.","PeriodicalId":270411,"journal":{"name":"Russian Journal of Allergy","volume":"295 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2023-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Russian Journal of Allergy","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.36691/rja3911","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0

Abstract

Objective: To assess the possibility of using a drug solution of Acarizax containing Derm house dust allergens. pteronyssinus and Derm. farinae in equal amounts - 12 SQ-HDM, in order to conduct skin prick tests to confirm the sensitization of patients to ODP.Methods: Skin prick tests with dilutions 1 tablet per 2.5 and 5 ml diluting liquid of the study drug with positive and negative controls. Statistical data processing was carried out using the Statistica 13.3 or IBM SPSS 17.0 software package. To analyze efficacy and safety data, standard parametric tests were used: Student's t-test for dependent/independent samples, analysis of variance (ANOVA) for repeated measurements, Mann-Whitney U-test, Shapiro-Wilk test. The analysis of AEs was planned to be based on an estimate of the frequency of AEs/serious AEs.Results: The correlation between the total level of specific IgE to tick allergens Derm was assessed. pteronyssinus and Derm. farinae measured at screening and papule size 20 minutes after application of the drug at a dilution of 1 tablet per 2.5 ml and 5 ml of diluting liquid - the correlation coefficient (r) in both groups (general) was 0.735 (high correlation), and 0.762 (high correlation) respectively. The result is statistically significant (p0.05) in both groups. A clinical trial has shown that the drug Acarizax, containing house dust allergens Derm. pteronyssinus and Derm.s farinae in equal amounts - 12 SQ-HDM, when used for the purpose of skin prick tests to confirm the sensitization of patients to ODP, is a safe and informative method.Conclusions: In order to conduct skin prick tests to confirm the sensitization of patients to ODP, the study drug can be used in a larger dilution - 1 tablet per 5 ml of diluting liquid. Acarizax medicinal product containing house dust allergens Derm. pteronyssinus and Derm. farinae in equal amounts - 12 SQ-HDM, when used for skin prick tests, is informative and well tolerated by patients.
使用Acarizax®药物溶液进行皮肤点刺试验,以确认患者对室内尘螨的敏感性。
目的:探讨含室内粉尘过敏原的阿螨灵药液应用的可行性。翼状窦和真皮。12 SQ-HDM,以便进行皮肤点刺试验以确认患者对ODP的致敏性。方法:皮肤点刺试验,每2.5 ml稀释剂1片,5 ml稀释剂为阳性对照和阴性对照。统计数据处理采用Statistica 13.3或IBM SPSS 17.0软件包。为分析疗效和安全性数据,采用标准参数检验:因循/独立样本采用学生t检验,重复测量采用方差分析(ANOVA), Mann-Whitney u检验,Shapiro-Wilk检验。对不良反应的分析计划基于对不良反应/严重不良反应频率的估计。结果:评估了蜱虫皮肤过敏原特异性IgE总水平的相关性。翼状窦和真皮。在每2.5 ml稀释1片和5 ml稀释液的条件下,在使用药物20分钟后测量筛检时的Farinae和丘疹大小,两组(一般)的相关系数(r)分别为0.735(高相关)和0.762(高相关)。两组比较差异均有统计学意义(p0.05)。一项临床试验表明,药物沙螨,含有房屋粉尘过敏原。翼状窦和真皮。当用于皮肤点刺试验以确认患者对ODP的致敏时,等量- 12 SQ-HDM是一种安全且信息丰富的方法。结论:为了进行皮肤点刺试验以确认患者对ODP的致敏性,研究药物可采用较大的稀释-每5ml稀释液1片。含有屋尘过敏原的螨螨医药产品。翼状窦和真皮。12 SQ-HDM,当用于皮肤点刺试验时,信息丰富且患者耐受性良好。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
CiteScore
0.50
自引率
0.00%
发文量
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信