AN ELECTROMYOGRAPHIC STUDY OF INFLUENCE OF TOXIC AMINES IN CANCER ON THE GASTROINTESTINAL MOVEMENT IN RABBITS

Abstract

An electromyographic study of the influence of six refined amines (histamine, acetylcholine, tyramine, putrescine, cadaverine and isoamylamine) on the movement of the gastrointestinal tract was carried out in 60 rabbits to evaluate the biological toxicity of these amines in cancer. Of these six amines, four amines except acetylcholine and tyramine were proved paper-chromatographically in cancerous tissue of the stomach by the author's colleagues, Tsushima et al. The following conclusions were made out of the results obtained: Histamine and acetylcholine slightly accelerate the peristaltic movement of the gastrointestinal tract, while the remaining amines have no effect under intraluminal administration in the amount of 0.3mg/kg. Each of the refined amines markedly accelerate peristalsis by dripping them in 0.5% solution on the serosal sites locally and also by administrating them 0.3mg/kg into the regional arteries. Intravenous administration of these amines shows no effect on the peristaltic movement in the group of rabbits with normal liver function, but accelerates markedly in the group of rabbits in which hepatic dysfuction is induced by carbon tetrachloride. The accelerating effect of these amines on the peristaltic movement is more predominant in the distal portion of the gastrointestinal tract than in the proximal portion.