Trent’anni fa i risultati del DCCT: cosa significarono allora e cosa rappresentano oggi

Abstract

The DCCT (Diabetes Control Complication Trials) has conclusively demonstrated in 1993 that good glycaemic control prevents the micro-angiopathy caused by chronic hyperglycaemia in T1DM. The subsequent follow-up study EDIC (Epidemiology of Diabetes Interventions and Complications) has demonstrated similar results for macro-angiopathy. Taken together, DCCT and EDIC strongly indicate the need for aggressive treatment of T1DM with intensive therapy to target near-normoglycaemia since clinical onset of T1DM to prevent long-term micro- and macro-vascular complications. Today and in the years to come, this message remains and will remain as fundamental as it was 30 years ago.