Correlation between the ankylosing spondyloarthritis disease activity score (ASDAS) and status of HLA-B27 and its subtype associated, to assess severity of spondyloarthritis

Abstract

Introduction : Ankylosing Spondylitis is a chronic and progressive inflammatory disease of the spine and enthesis affecting skeletal and extra skeletal tissues and is largely associated with HLA B27. However, more than 95% of individuals in the general population with this gene never develop Ankylosing Spondylitis. A lot of studies have shown that HLA B27 reveals remarkable polymorphism with an ever-increasing number of alleles and atleast 105 subtypes of HLA B27 is now known. Correlating the severity of Ankylosing Spondylitis using ASDAS score with the presence of a particular subtype of HLA B27 can help in segregating a high-risk population and subjecting them to an aggressive and early onset treatment for greater therapeutic benefits and thus reducing the disability burden on the society. Objective: To study the correlation between the disease severity and the HLA-B27 subtype associated. Thus, studying the influence of a particular HLA-B27 subtype on the disease severity that would be quantified using ASDAS. Method : This is retrospective as well as a prospective study in which fifty consecutive patients of Ankylosing spondylitis of the patient.