Comparative Study of Zinc and Probiotics versus Zinc Alone Therapy in Children with Acute Watery Diarrhea

TAJ: Journal of Teachers Association Pub Date : 2018-12-03 DOI:10.3329/taj.v30i2.39135

Mst Musarrat Sultana, M. Islam, Shahana Akhter, M. B. Hossain, Md Sanaul Haque Mia

{"title":"Comparative Study of Zinc and Probiotics versus Zinc Alone Therapy in Children with Acute Watery Diarrhea","authors":"Mst Musarrat Sultana, M. Islam, Shahana Akhter, M. B. Hossain, Md Sanaul Haque Mia","doi":"10.3329/taj.v30i2.39135","DOIUrl":null,"url":null,"abstract":"Objective: Diarrhea is a common problem in our country especially children. There were many treatment options for acute watery diarrhea in addition to oral rehydration saline for reducing the severity of acute watery diarrhea. The aim of this study was to compare the efficacy of zinc & probiotics combination therapy to zinc alone therapy in reducing the severity of acute diarrhea.Method: This was a randomized controlled trial type study, conducted at department of pediatrics Rajshahi Medical College Hospital from July 2014 to June 2016. A total of 110 numbers of children ages 6 months to 5 years with acute watery diarrhea were enrolled those who were fulfilled the selection criteria. They were divided into two groups. Group A (n=55) received zinc-probiotics combination therapy and group B (n=55) received zinc only. Measurement of disease severity was based on the frequency of diarrhea (times/day) and duration of diarrhea (hours) after initial drug consumption.Result: Among the study population 56% male &44% female in group A and 58% male & 42% female in group B. Duration of acute watery diarrhea was significantly reduced in group A than group B(56.22 versus 70.69 hours respectively), (P-0.002)and frequency of stool also reduced in group A than group B(3.92 versus 7.15 times/day) on day 2 (P-0.002). Consistency of stool also improved in group A than group B[liquid stool12(21.8%) versus 25(45.5%), (P-0.015) on day 1, semi-liquid stool 4 (8.2%) versus 16 (30.8%), (P-0.004) on day 2, formed stool 29 (52.73%) versus 16(29.09%), P-0.004 on day 2 respectively].Conclusion: Combination therapy was more effective in reducing the severity of acute watery diarrhea than zinc alone therapy in children.TAJ 2017; 30(2): 32-38","PeriodicalId":373921,"journal":{"name":"TAJ: Journal of Teachers Association","volume":"1 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2018-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"TAJ: Journal of Teachers Association","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.3329/taj.v30i2.39135","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}

引用次数: 0

Abstract

Objective: Diarrhea is a common problem in our country especially children. There were many treatment options for acute watery diarrhea in addition to oral rehydration saline for reducing the severity of acute watery diarrhea. The aim of this study was to compare the efficacy of zinc & probiotics combination therapy to zinc alone therapy in reducing the severity of acute diarrhea.Method: This was a randomized controlled trial type study, conducted at department of pediatrics Rajshahi Medical College Hospital from July 2014 to June 2016. A total of 110 numbers of children ages 6 months to 5 years with acute watery diarrhea were enrolled those who were fulfilled the selection criteria. They were divided into two groups. Group A (n=55) received zinc-probiotics combination therapy and group B (n=55) received zinc only. Measurement of disease severity was based on the frequency of diarrhea (times/day) and duration of diarrhea (hours) after initial drug consumption.Result: Among the study population 56% male &44% female in group A and 58% male & 42% female in group B. Duration of acute watery diarrhea was significantly reduced in group A than group B(56.22 versus 70.69 hours respectively), (P-0.002)and frequency of stool also reduced in group A than group B(3.92 versus 7.15 times/day) on day 2 (P-0.002). Consistency of stool also improved in group A than group B[liquid stool12(21.8%) versus 25(45.5%), (P-0.015) on day 1, semi-liquid stool 4 (8.2%) versus 16 (30.8%), (P-0.004) on day 2, formed stool 29 (52.73%) versus 16(29.09%), P-0.004 on day 2 respectively].Conclusion: Combination therapy was more effective in reducing the severity of acute watery diarrhea than zinc alone therapy in children.TAJ 2017; 30(2): 32-38

查看原文本刊更多论文

锌和益生菌与单独锌治疗儿童急性水样腹泻的比较研究

目的:腹泻是我国常见病，尤其是儿童腹泻。急性水样腹泻的治疗方法有很多，除了口服补液盐水可以减轻急性水样腹泻的严重程度。本研究的目的是比较锌和益生菌联合治疗与锌单独治疗在减轻急性腹泻严重程度方面的疗效。方法:本研究为随机对照试验型研究，于2014年7月至2016年6月在Rajshahi医学院附属医院儿科开展。符合选择标准的6个月至5岁急性水样腹泻患儿共入组110例。他们被分成两组。A组(n=55)接受锌-益生菌联合治疗，B组(n=55)只接受锌治疗。疾病严重程度的测量是基于首次用药后腹泻的频率(次/天)和腹泻持续时间(小时)。结果:在研究人群中，A组有56%的男性和44%的女性，B组有58%的男性和42%的女性，急性水样腹泻的持续时间明显少于B组(分别为56.22和70.69小时)(P-0.002)，第2天A组的大便次数也明显少于B组(3.92次/天比7.15次/天)(P-0.002)。A组大便的稠度也比B组有所改善[第1天液体大便12(21.8%)比25(45.5%)，(P-0.015)，半液体大便4(8.2%)比16(30.8%)，第2天(P-0.004)，形成大便29(52.73%)比16(29.09%)，第2天P-0.004]。结论:复方锌对减轻儿童急性水样腹泻的严重程度有较好的疗效。泰姬酒店2017;30 (2):

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

TAJ: Journal of Teachers Association

自引率

0.00%

发文量