Aerosol drug delivery to the lung periphery using nanoscale technologies

Abstract

Two applications of nanotechnoiogy to the AERx/spl reg/ drug delivery system are presented. Improved delivery performance is demonstrated using nanoscale nozzles. This gives higher emitted doses with reduced aerosol particle sizes, leading to deeper penetration of the drug into the lung periphery. Expanded capabilities are demonstrated using n a nanosuspensions. For example, drugs that are otherwise poorly soluble can be delivered to the lung periphery using nanosuspensions.