A Multifactorial Analysis of Ebola Virus Glycoprotein Receptor BindingDomain

Abstract

An analysis of the receptor-binding domain (RBD) of the ZEBOV-Makona glycoprotein is presented, based upon the following four factors: information entropy (H), protein conformation, thermal imprint (B factor) and predicted epitope activity (Bepipred Score). It was found that the position of maximum information entropy (Hmax) was located within a helical pentapeptide component of a 31-mer peptide in which H=0 at each amino acid except at the amino acid position where H=Hmax. It is proposed that identification of these RBD peptide components and characteristics can help facilitate efficient design of an anti-Ebola vaccine.