Electrically isolated buried electrode biosensor for detecting folic acid concentration

Abstract

The current study sought to detect and quantify different folic acid concentrations in Phosphate Buffer Saline (PBS) by employing Electrical Impedance Spectroscopy (EIS).This technique provides a simple, rapid, precise and cost-effective platform for folic acid monitoring. An on-wafer platform has been developed to perform the necessary electrical measurements. Variation of electrical parameters such as impedance, capacitance and conductance for six different concentrations ranging from 4 mg/dl to 6 mg/dl are analyzed. The capacitance and conductance are observed to increase whereas impedance has been found to decrease with increasing folic acid content in saline. FT-MIR spectrum shows distinct confirmatory peaks relevant to the folic acid constituents in the IR range 4000 cm-1 to 400 cm-1.