Acinetobacter spp.: regional features of epidemiology

Abstract

Purpose of the study . Investigation of the epidemiological process features in healthcare settings. Materials and  methods . Here we carried out  a retrospective  epidemiological study  in Kemerovo  Region  including 143 768  patient outcomes between  2012 and 2018. Results and conclusions . Average annual incidence of Acinetobacter  spp. infection/colonization was  13,14  per 1000 patients  (95% CI [13,14–14,35])   with range between  7,76 (95% CI [7,13–8,02]) to 20,58  (95% CI [20,04–20,82]). We revealed a trend to decreasing incidence of Acinetobacter spp. infection/colonization (average  growth rate 54,9%, y = -2,0438x + 21,261, R² = 0,93), without any notable seasonality  and or repeating cycles. Case-control  study was then conducted among  patients  who  were  admitted  to  the  neurology  and  neurosurgery  units. Patients  with stroke  has 4,29-fold  higher risk of Acinetobacter  spp. infection/colonization  (CI = 2,19–8,78) as  compared  to  those without. The proportion of carbapenem  resistant Acinetobacter baumannii strains was 58% and raised 3-fold from 2012 to 2018. The RAPD-PCR  genotyping with amplification of the variable integron I fragment detected the circulation of two integron-positive A. baumannii clones in 2018 in these  units.