A Preliminary Study of Convolutional Neural Network Architectures for Breast Cancer Image Classification

S. Khairi, M. Bakar, M. A. Alias, S. A. Bakar, C. Liong
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Abstract

Breast cancer is one of the most common cancer with high mortality rate worldwide. Classification of breast cancer images is an important clinical issue related to accurate early diagnosis and treatment plan preparation. However, it is still uncertain which model is effective for classifying breast cancer images. For medical image analysis, deep learning models have proved to yield excellent outcomes in classification tasks. Hence, this study compared the performance of the most common deep learning models which is convolutional neural networks for breast cancer classification on the histopathology images. A total of 7,909 images were extracted from BreakHis database that comprised of 2,480 benign and 5,429 malignant samples. The images are of four different magnifications which are 40X, 100X, 200X and 400X. This study focused on comparing the state-of the-art architectures, namely, AlexNet, GoogleNet and ResNet 18 to evaluate the performance of model in classifying the breast cancer images. The models were examined through a multiclass classification analysis in terms of accuracy, sensitivity, specificity and F-Score. The experimental results indicated that ResNet18 was the most effective method with an accuracy of 94.8% with 70 min 31 sec time taken for computation. The research findings are expected to facilitate the radiologist in classifying the breast cancer images and hence planning proper treatment for patients.
卷积神经网络结构在乳腺癌图像分类中的初步研究
乳腺癌是世界范围内死亡率最高的常见癌症之一。乳腺癌影像的分类是一个重要的临床问题,关系到早期准确诊断和制定治疗方案。然而,哪种模型对乳腺癌图像分类是有效的仍然是不确定的。对于医学图像分析,深度学习模型已被证明在分类任务中产生出色的结果。因此,本研究比较了最常见的深度学习模型卷积神经网络在乳腺癌组织病理图像分类上的表现。BreakHis数据库共提取了7909张图像,其中包括2480张良性样本和5429张恶性样本。这些图像有四种不同的放大倍数,分别是40倍、100倍、200倍和400倍。本研究的重点是比较目前最先进的架构,即AlexNet, GoogleNet和ResNet 18,以评估模型在乳腺癌图像分类中的性能。通过多类分类分析对模型的准确性、敏感性、特异性和F-Score进行检验。实验结果表明,ResNet18是最有效的方法,计算时间为70 min 31 sec,准确率为94.8%。研究结果将有助于放射科医生对乳腺癌影像进行分类,从而为患者制定适当的治疗方案。
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