Development of Chitosan Hemostatic Sponges with Different Solvents and Tranexamic Acid

Abstract

Blood loss during surgery and combat trauma are still main complications leading patient death. Topical hemostasis in case of diffuse bleeding over past 2 decades have resulted in low mortality and morbidity rates but relatively high cost limited their application in low- and middle-income countries, that stimulate investigation of effective and low cost materials. In recent paper chitosan sponges with different solvents (acetic, ascorbic, lactic and oxalic acids) with/without tranexamic acid were made as a hemostatic sponges. SEM and Degradation test used for physical characterization and Cell Toxicity test and Blood Clotting Test - for biological evaluation. Based on structural features and in-vitro studies, chitosan-acetate sponge with TXA is the best choice for development of high efficient hemostatic materials.