Therapeutic Implication of Herbal Phytoconstituents in Alzheimer’s Disease

Abstract

Introduction: Herbal plants have been widely used in traditional medicines for improving cognitive decline and age-related loss of memory since ancient times. Medicinal plants, it is claimed, contain various active components, and they have a widely used synthetic medication option for treating cognitive and associated issues. Herbal medicines have aided in advancing medicine, and several innovative pharmaceuticals have already developed. For example, much research has backed the use of phytoconstituents in herbal medicines to treat Alzheimer’s disease (AD). Progressive memory loss, linguistic difficulties, melancholy, anxiety, mood swings, and psychosis are some of these symptoms. Objective: A systemic literature review of Bentham, Scopus, PubMed, Medline, and EMBASE (Elsevier) database was carried out to understand the study till March 2021. Conclusion: Although neurofibrillary tangle and cholinergic dysfunction, -amyloid plaquesdevelopment are critical features of AD, it is also linked to oxidative damage, disruption of other neurotransmitters, high levels of AGEs, neuroinflammation, hereditary and environmental variables. On the one hand, because of this complex etiology, responses to routinely used medications like memantine, donepezil, galantamine, and rivastigmine are unpredictable and frequently poor. On the other hand, their nonspecific anti-inflammatory and antioxidant effect and particular cholinesterase inhibitory activity support the use of herbal medications. Herbal drugs are also gaining popularity as a result of their supposed efficacy, safety, and accessibility.