Non-specifically bound IgG and Fc gamma receptors in human malignant tissues.

Abstract

Similar amounts of non-specifically bound IgG were found in the eluates of the same tissues both after the Fc gamma receptor activity (FcRA) had been abolished by disrupting the tissue and when FcRA was intact. This indicates that the non-specifically bound IgG is either not attached to the FcR, or that only the free FcR were abolished. No FcRA was detected in the supernatant of the tissue from which the FcRA was abolished, thus indicating that the FcRA was destroyed.