{"title":"Problems of dose-response studies in chemical carcinogenesis with special reference to N-nitroso compounds.","authors":"D Schmähl","doi":"10.3109/10408447909037485","DOIUrl":null,"url":null,"abstract":"<p><p>Dose-response studies in chemical carcinogenesis are a valuable method for evaluating the risk involved by a certain carcinogen. This article deals with the methods that are presently applied for dose-response studies. It is emphasized that there are many possible mistakes that are already hidden in the method itself; a critical approach is made to the indicative value of dose-response studies. It is also emphasized that the conclusions which may be drawn from dose-response studies can always only be extrapolative but never mathematically calculable. Finally, some practical examples for dose-response studies with n-nitroso compounds are described.</p>","PeriodicalId":75752,"journal":{"name":"CRC critical reviews in toxicology","volume":"6 3","pages":"257-81"},"PeriodicalIF":0.0000,"publicationDate":"1979-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/10408447909037485","citationCount":"15","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"CRC critical reviews in toxicology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.3109/10408447909037485","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 15
Abstract
Dose-response studies in chemical carcinogenesis are a valuable method for evaluating the risk involved by a certain carcinogen. This article deals with the methods that are presently applied for dose-response studies. It is emphasized that there are many possible mistakes that are already hidden in the method itself; a critical approach is made to the indicative value of dose-response studies. It is also emphasized that the conclusions which may be drawn from dose-response studies can always only be extrapolative but never mathematically calculable. Finally, some practical examples for dose-response studies with n-nitroso compounds are described.
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