Sinonasal Melanoma: About Two Cases and Literature Review

Abstract

anatomopathological study of the specimen numerous arranged in tangled bundles, dissociated by more or thickened fibrous trabeculae, the tumor cells are sometimes strongly pigmented and represent voluminous nuclei, The mitotic index is evaluated at 30 mitoses per 10 CFG. This tumor destroys the on the surface and infiltrates the dermis and hypodermis as well as the nostril cartilage. The breslow index was evaluated at 9 mm in the deepest zone, no vascular emboli or peri-nervous sheathing, the immunohistochemical study showed tumor cells positive for anti- PS100, anti-HMB45 and anti-Melan A, anti-CD34, anti-CK, anti-AMI, anti-desmin, anti- Hcaldesmone were negative in the tumor cells; the histological and IHC aspect of a desmoplastic malignant melanoma, ulcerated, Clark level V was retained. The case was discussed in a multidisciplinary ENT (ear - nose-throat) oncology consultation meeting and the decision was to perform a recent extension assessment and radiotherapy. ABSTRACT Mucosal malignant melanoma of the nasal cavity and paranasal sinuses is a rare tumor, given their rarity and the absence of randomized trials, the diagnostic and therapeutic management of these tumors is difficult. We report two cases of mucosal malignant melanoma of nasal cavity and through the literature data we review the different aspects of this rare entity. Both patients underwent surgical excision with removal of the tumor. The radiotherapy was delivered with intensity modulated radiation therapy (IMRT) technique. The prognosis remains unfavorable despite therapeutic progress.