Possible involvement of no–synthase in inotropic effect of 4’,5–dihydroxy–7–methoxyflavon in rat cardiac muscle

Abstract

Treatment of cardiovascular diseases includes a wide range of pharmacological drugs, and plant remedies are suitable alternatives to synthetic drugs due to their availability, non–proarrhythmic characteristics, and minimal side effects.1 Medicinal plants distributed in the Central Asia and China provides abundant and precious medicinal resources for the Traditional Medicine in treating diseases.2 Flavonoids are unique secondary metabolites are synthesized in almost all plant cells, exhibiting high biological activity and due to their properties increasingly finding wide practical application in pharmacology and medicine. A wide range of biological activities and low toxicity puts them in a row promising compounds in this respect. Therefore, in pharmaceutical industry researches find cure against many various diseases, the direction of tendency is observed towards the growth of interest to search and create medical products based on bioflavonoids.3–8 Also, nowadays, in chemical researches have extracted and identified many bioflavonoid from plants.7,9–12 However, their mechanisms of cardio pharmacological impact have not been studied yet. Therefore, the aim of the present study was to involvement of NO–synthase in inotropic effect of 4’,5–dihydroxy–7– methoxyflavon in rat papillary muscle.